On April 11, Frank de Gruijl from the Leiden University Medical Center/LUMC, Netherlands evaluated at the F1000Biology an article published in PLoSONE (The Vitamin D Receptor Is a Wnt Effector that Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis.Pálmer HG, Anjos-Afonso F, Carmeliet G, Takeda H, Watt FM. PLoS ONE 2008, 3(1):e1483). He rated this article with the F1000 factor of 6.00; this value denotes that the article is of major interest to community in the corresponding research area and that every researcher in the field must read it. Here are the evaluator's specific remarks:
"Both the WNT pathway and the vitamin D receptor (VDR) are known to be important to the development of hair follicles, but the latter can now also be considered a downstream transcription factor of WNT, next to its canonical transcription factor TCF/Lef. The branching point is beta-catenin, which can activate both transcription factors. Remarkably, some beta-catenin-responsive genes have VDR, but not TCF/Lef promoter sites. The ligand-activated VDR was shown to prevent follicular tumor formation by beta-catenin, most likely by restoring natural differentiation, and infiltrative human basal cell carcinomas were found to have low VDR expression next to a clear nuclear beta-catenin expression".
On an average about 5% of PLoSONE articles are evaluated on the Faculty of 1000 at a given time, which roughly means a fourth position in terms of number of evaluations, after Science (~17% of the published articles evaluated), Nature (~15% of the published articles evaluated) and PNAS(~15% of the published articles evaluated).
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