This Week's Evaluations at Faculty of 1000 Medicine

The following important articles were evaluated this week at the Faculty of 1000 Medicine:

1) Genetics of gene expression and its effect on disease. Emilsson V, Thorleifsson G, ..., Schadt EE, Stefansson K Nature 2008 Mar 27 452 (7186):423-8 Section Epidemiology Recommended by Dominique Langin "This study is the first large-scale attempt to combine gene expression with DNA and complex trait..." [F1000 Factor 6.0 - Must Read]

2) Increased risk of recurrence after hormone replacement therapy in breast cancer survivors. Holmberg L, Iversen OE, ..., Maenpa J, HABITS Study Group J Natl Cancer Inst 2008 Apr 2 100 (7):475-82 Section Epidemiology Recommended by Pagona Lagiou "In my opinion, and according to this study, clinicians following up breast cancer survivors shoul..." [F1000 Factor 6.0 - Must Read]

3) Variation in HIV-1 set-point viral load: epidemiological analysis and an evolutionary hypothesis. Fraser C, Hollingsworth TD, ..., de Wolf F, Hanage WP Proc Natl Acad Sci U S A 2007 Oct 30 104 (44):17441-6 Section Global health Recommended by Isaac Zulu with Kayvon Modjarrad "This study models the optimal transmission dynamics of HIV-1 virus. Its conclusions may have publ..." [F1000 Factor 3.0 - Recommended]

4) Survival among patients with kidney failure in Jalisco, Mexico. Garcia-Garcia G, Briseño-Rentería G, ..., Gill J, Tonelli M J Am Soc Nephrol 2007 Jun 18 (6):1922-7 Section Global health Recommended by Neil Turner "The harsh realities of end stage renal disease (ESRD) in a country with limited provision are cle..." [F1000 Factor 3.0 - Recommended]

5) Host defense peptide LL-37, in synergy with inflammatory mediator IL-1beta, augments immune responses by multiple pathways. Yu J, Mookherjee N, ..., Rehaume L, Hancock RE J Immunol 2007 Dec 1 179 (11):7684-91 Section Allergy & clinical immunology Recommended by Helgi Valdimarsson with Sigrun Sigurdardóttir "This study indicates that the antimicrobial peptide cathelicidin ll-37 has a highly selective imm..." [F1000 Factor 3.0 - Recommended]